![]() ![]() One Compartment Model Absorption Rate BioavailabilityĬL ka XG = Dose If F1, then the calculation gives a CL value that is larger than the true value.Ģ8 PK Parameters from single-dose plasma concentration profile The ratio Dose/AUC gives the true value of CL only when F=1. Dose _Cmax _Tmax _t1/2 _AUCĢ4 Shape parameters as functions of PK parametersĢ7 PK Parameters from single-dose plasma concentration profile.Use shape parameters to deduce changes in PK parameters: ka, CL, V, Fġ7 v CL ka Tmax At the peak Cp, dCp/dt = 0Ģ0 ka ka _Cmax _Tmax _t1/2 _AUCĢ1 CL CL _Cmax _Tmax _t1/2 _AUCĢ2 F Cp v CLġ5 Absorption The slope of the log-linear phase reflects the smaller of ka and KE.ġ6 Absorption Shape parameters Cmax Tmax AUC t1/2.MB Murine CL = CLH + CLR + CLP CLH CLR DB Durine CLP Expired airġ2 One Compartment Model A two-fold change in CL:ġ3 One Compartment Model A two-fold change in V:ġ4 One Compartment Model Absorption Inputĭrug enters body by a first-order, monoexponential process. 2.3 x Slope = CL/V = KE V = Dose ÷ Cp,o CL = KEV KE t1/2 CL Vġ0 Calculation of AUC Trapezoidal Method, R&T, p.469 AUCt1-t2 = the area under the curve from time = t1 to time = t2.ĩ Summary of Wednesday v I.V. KE t1/2 CL VĨ Area Under the Curve AUC = the area under the Cp,t profile, from time = 0 to time = , usually for a single dose. Half Life and KE depend on both CL and V a change in either CL or V will cause a change in t1/2 and KE. Cp = -dCp/dt Cp = Cp,oe-(CL/V)tģ Example: Dose = 300 mg, as iv bolus V = 35 L and CL = 2 L/hĬp,o = Dose/V = 300 mg ÷ 35 L = 8.57 mg/LĤ One Compartment Model Cp = Cp,oe-(CL/V)t.One Compartment Model IV Bolus AbsorptionĢ One Compartment Model v Simplest compartmental modelīody is assumed to behave as if it were a single, well stirred fluid. ![]()
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